MS-ISAC CYBERSECURITY ADVISORY - Multiple Vulnerabilities in Sante PACS Server Could Allow for Remote Code Execution - PATCH NOW - TLP: CLEAR

Multiple vulnerabilities have been discovered in Sante PACS Server, the most severe of which could allow for remote code execution. Successful exploitation of the most severe vulnerabilities could allow for remote code execution in the context of the system. Depending on the privileges associated with the system, an attacker could then install programs; view, change, or delete data. 

There are currently no reports of these vulnerabilities being exploited in the wild.

Multiple vulnerabilities have been discovered in Sante PACS Server, the most severe of which could allow for remote code execution. Details of these vulnerabilities are as follows:

Tactic: Initial Access (TA0001):

Technique: Exploit Public-Facing Application (T1190):

• During login to the web server in "Sante PACS Server.exe", OpenSSL function EVP_DecryptUpdate is called to decrypt the username and password. A fixed 0x80-byte stack-based buffer is passed to the function as the output buffer. An stack-based buffer overflow exists if a long encrypted username or password is supplied by an unauthenticated remote attacker. (CVE-2025-2263)
• A Path Traversal Information Disclosure vulnerability exists in "Sante PACS Server.exe". An unauthenticated remote attacker can exploit it to download arbitrary files on the disk drive where the application is installed. (CVE-2025-2264)

Details of lower severity vulnerabilities:

• The password of a web user in "Sante PACS Server.exe" is zero-padded to 0x2000 bytes, SHA1-hashed, base64-encoded, and stored in the USER table in the SQLite database HTTP.db. However, the number of hash bytes encoded and stored is truncated if the hash contains a zero byte. (CVE-2025-2265)
• A denial-of-service vulnerability exists in the "GetWebLoginCredentials" function in "Sante PACS Server.exe". (CVE-2025-2284)

Successful exploitation of the most severe vulnerabilities could allow for remote code execution in the context of the system. Depending on the privileges associated with the system, an attacker could then install programs; view, change, or delete data.

We recommend the following actions be taken:

• Apply appropriate updates provided by Santesoft to vulnerable systems immediately after appropriate testing. (M1051: Update Software)
• Safeguard 7.1 : Establish and Maintain a Vulnerability Management Process: Establish and maintain a documented vulnerability management process for enterprise assets. Review and update documentation annually, or when significant enterprise changes occur that could impact this Safeguard.
• Safeguard 7.2: Establish and Maintain a Remediation Process: Establish and maintain a risk-based remediation strategy documented in a remediation process, with monthly, or more frequent, reviews.
• Safeguard 7.4: Perform Automated Application Patch Management: Perform application updates on enterprise assets through automated patch management on a monthly, or more frequent, basis.
• Safeguard 7.5 : Perform Automated Vulnerability Scans of Internal Enterprise Assets: Perform automated vulnerability scans of internal enterprise assets on a quarterly, or more frequent, basis. Conduct both authenticated and unauthenticated scans, using a SCAP-compliant vulnerability scanning tool.
• Safeguard 7.7: Remediate Detected Vulnerabilities: Remediate detected vulnerabilities in software through processes and tooling on a monthly, or more frequent, basis, based on the remediation process.
• Safeguard 12.1: Ensure Network Infrastructure is Up-to-Date: Ensure network infrastructure is kept up-to-date. Example implementations include running the latest stable release of software and/or using currently supported network-as-a-service (NaaS) offerings. Review software versions monthly, or more frequently, to verify software support.
• Safeguard 18.1: Establish and Maintain a Penetration Testing Program: Establish and maintain a penetration testing program appropriate to the size, complexity, and maturity of the enterprise. Penetration testing program characteristics include scope, such as network, web application, Application Programming Interface (API), hosted services, and physical premise controls; frequency; limitations, such as acceptable hours, and excluded attack types; point of contact information; remediation, such as how findings will be routed internally; and retrospective requirements.
• Safeguard 18.2: Perform Periodic External Penetration Tests: Perform periodic external penetration tests based on program requirements, no less than annually. External penetration testing must include enterprise and environmental reconnaissance to detect exploitable information. Penetration testing requires specialized skills and experience and must be conducted through a qualified party. The testing may be clear box or opaque box.
• Safeguard 18.3: Remediate Penetration Test Findings: Remediate penetration test findings based on the enterprise’s policy for remediation scope and prioritization.

• Apply the Principle of Least Privilege to all systems and services. Run all software as a non-privileged user (one without administrative privileges) to diminish the effects of a successful attack. (M1026: Privileged Account Management)
• Safeguard 4.7: Manage Default Accounts on Enterprise Assets and Software: Manage default accounts on enterprise assets and software, such as root, administrator, and other pre-configured vendor accounts. Example implementations can include: disabling default accounts or making them unusable.
• Safeguard 5.5: Establish and Maintain an Inventory of Service Accounts: Establish and maintain an inventory of service accounts. The inventory, at a minimum, must contain department owner, review date, and purpose. Perform service account reviews to validate that all active accounts are authorized, on a recurring schedule at a minimum quarterly, or more frequently.

• Vulnerability scanning is used to find potentially exploitable software vulnerabilities to remediate them. (M1016: Vulnerability Scanning)
• Safeguard 16.13: Conduct Application Penetration Testing: Conduct application penetration testing. For critical applications, authenticated penetration testing is better suited to finding business logic vulnerabilities than code scanning and automated security testing. Penetration testing relies on the skill of the tester to manually manipulate an application as an authenticated and unauthenticated user.

• Architect sections of the network to isolate critical systems, functions, or resources. Use physical and logical segmentation to prevent access to potentially sensitive systems and information. Use a DMZ to contain any internet-facing services that should not be exposed from the internal network. Configure separate virtual private cloud (VPC) instances to isolate critical cloud systems. (M1030: Network Segmentation)
• Safeguard 12.2: Establish and Maintain a Secure Network Architecture: Establish and maintain a secure network architecture. A secure network architecture must address segmentation, least privilege, and availability, at a minimum.

• Use capabilities to detect and block conditions that may lead to or be indicative of a software exploit occurring. (M1050: Exploit Protection)
• Safeguard 10.5: Enable Anti-Exploitation Features: Enable anti-exploitation features on enterprise assets and software, where possible, such as Microsoft® Data Execution Prevention (DEP), Windows® Defender Exploit Guard (WDEG), or Apple® System Integrity Protection (SIP) and Gatekeeper™.